Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice
Identifieur interne : 002758 ( Main/Exploration ); précédent : 002757; suivant : 002759Induction of homotypic and heterotypic T- and B-cell immunity with influenza A virus in mice
Auteurs : D. Armerding [Autriche] ; E. Liehl [Autriche]Source :
- Cellular Immunology [ 0008-8749 ] ; 1981.
English descriptors
- Teeft :
- Academic press, Allantoic fluid, Antibody titers, Armerding, Assay, Assay system, Attenuated, Attenuated virus strains, Attenuated viruses, Cold recombinants, Culture supernatants, Cytolytic, Cytolytic activity, Cytotoxic, Cytotoxicity assay, Different results, Effector, Effector cells, First series, Heterologous, Heterologous influenza substrains, Heterologous virus, Heterotypic, Heterotypic influenza, Heterotypic protection, Heterotypic virus, Honl, Honl virus, Hswlnl, Hswlnl hznz, Immunity, Immunol, Immunological memory, Infectious virus, Influenza, Influenza subtype, Influenza virus, Influenza viruses, Killer responses, Latter case, Liehl, Lymphocyte, Mice unprimed, Microtiter method, Mouse, Normal mice, Normal rabbit serum, Other viruses, Presensitized mice, Primary response, Primary responses, Primary sensitization, Procedural guide, Respective influenza, Same route, Schild, Secondary responses, Sensitizing virus, Specific honi, Spleen cells, Substrain specificity, Substrains, Subtypes, Such antisera, Target cell infection, Target cells, Target virus, Unprimed mice, Virus, Virus infection, Virus preparation, Virus preparations, Virus strain, Virus strains, Virus substrains, Virus subtypes, Vivo, Vivo induction, Vivo systems.
Abstract
Abstract: Infection of mice with live influenza A virus induces cytolytic T lymphocytes (CTL) as well as B cells capable of reacting with target cells infected with the appropriate virus subtypes. In Balb/c mice CTL reveal a broad cross-reactivity against all influenza A substrains known. In contrast B-cell responses are restricted to virus subtypes which are identical in regard to the hemagglutinin (HA) of the sensitizing virus. Reinfection with homologous live influenza virus within 6–7 months results in no or in a drastically diminished B-cell response as compared to a priming situation and fails to induce CTL. Inability to induce secondary immunity to homologous influenza virus was correlated with the presence of circulating antibodies specific for the sensitizing virus subtype. Cross-boosting with heterologous live influenza A virus induces homotypic and heterotypic CTL and B-cell immunity with characteristics of secondary responses. Preparations of inactivated intact influenza virus are unable to reactivate CTL memory in vivo but induce B-cell activity. B-cell responses stimulated by this procedure are restricted to the boosting virus. Attenuated viruses, which are produced by recombination of wild strains with cold-adapted strains, are also efficient in stimulating in vivo CTL memory if used for cross-boosting.
Url:
DOI: 10.1016/0008-8749(81)90253-7
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">Abstract: Infection of mice with live influenza A virus induces cytolytic T lymphocytes (CTL) as well as B cells capable of reacting with target cells infected with the appropriate virus subtypes. In Balb/c mice CTL reveal a broad cross-reactivity against all influenza A substrains known. In contrast B-cell responses are restricted to virus subtypes which are identical in regard to the hemagglutinin (HA) of the sensitizing virus. Reinfection with homologous live influenza virus within 6–7 months results in no or in a drastically diminished B-cell response as compared to a priming situation and fails to induce CTL. Inability to induce secondary immunity to homologous influenza virus was correlated with the presence of circulating antibodies specific for the sensitizing virus subtype. Cross-boosting with heterologous live influenza A virus induces homotypic and heterotypic CTL and B-cell immunity with characteristics of secondary responses. Preparations of inactivated intact influenza virus are unable to reactivate CTL memory in vivo but induce B-cell activity. B-cell responses stimulated by this procedure are restricted to the boosting virus. Attenuated viruses, which are produced by recombination of wild strains with cold-adapted strains, are also efficient in stimulating in vivo CTL memory if used for cross-boosting.</div>
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